GSK3beta突变体的信号传导
中文名称
通路描述
GSK3beta在CML干细胞中发生同框错义剪接，导致产生缺乏AXIN和FRAT结合域的突变蛋白。含有该突变GSK3beta的细胞中核β-catenin水平升高，并增强TCF依赖的报告活性（Jamieson et al, 2008; Abrahamsson et al, 2009）。
英文描述
Signaling by GSK3beta mutants GSK3beta is subject to in-frame missplicing in CML stem cells resulting in the production of mutant protein that lacks the AXIN and FRAT binding domains. Cells containing this mutant GSK3beta show elevated levels of nuclear beta-catenin and enhanced TCF-dependent reporter activity (Jamieson et al, 2008; Abrahamsson et al, 2009).
所含基因
13 个基因