LRP5突变体的信号传导
中文名称
通路描述
LRP5在乳腺癌和甲状旁腺癌中发生同框错义剪接事件，导致蛋白对WNT拮抗剂DKK1的抑制不敏感。突变蛋白的表达导致活性未磷酸化的β-catenin水平升高，并增强TCF依赖的WNT信号传导，促进细胞增殖（Bjorklund et al 2007a, b; Bjorklund et al, 2009）。
英文描述
Signaling by LRP5 mutants LRP5 is subject to an in-frame missplicing event in breast and parathyroid cancers that renders the protein insensitive to inhibition by the WNT antagonist DKK1. Expression of the mutant protein results in elevated levels of active, unphosphorylated beta-catenin and enhanced TCF-dependent WNT-signaling, promoting cellular proliferation (Bjorklund et al 2007a, b; Bjorklund et al, 2009).
所含基因
5 个基因