RNF43突变体的信号传导
中文名称
通路描述
RNF43和相关的蛋白ZNRF3是E3泛素连接酶，通过下调细胞表面的FZD受体来负向调节WNT信号传导（Mukai et al, 2010; Hao et al, 2012）。在胰腺和结直肠癌中发现的增强WNT信号传导的RNF43框移失功能突变已被鉴定；这些细胞的增殖依赖于分泌的WNT，因为它们的生长被Porcupine抑制剂LGK974处理细胞所阻断（Koo et al, 2012; Jiang et al, 2013）
英文描述
Signaling by RNF43 mutants RNF43 and related protein ZNRF3 are E3 ubiquitin ligases that negatively regulate WNT signaling by downregulating FZD receptors at the cell surface (Mukai et al, 2010; Hao et al, 2012). Frameshift loss-of-function mutations in RNF43 that enhance WNT signaling have been identified in pancreatic and colorectal cancers; the proliferation of these cells is dependent on the presence of secreted WNT, as their growth is abrogated by treatment of cells with the Porcupine inhibitor LGK974 (Koo et al, 2012; Jiang et al, 2013).
所含基因
6 个基因