CTNNB1 S37 突变体未磷酸化
中文名称
通路描述
β-catenin 的 S37 突变体干扰 GSK3 的磷酸化，稳定蛋白质，导致 WNT 通路信号增强 (Nhieu et al, 1999; Clements et al, 2002; 综述于 Polakis, 2000)。S37 突变体已在脑、肝脏、卵巢和结肠等癌症中被鉴定 (综述于 Polakis, 2000)。
英文描述
CTNNB1 S37 mutants aren't phosphorylated S37 mutations of beta-catenin interfere with GSK3 phosphorylation and stabilize the protein, resulting in enhanced WNT pathway signaling (Nhieu et al, 1999; Clements et al, 2002; reviewed in Polakis, 2000). S37 mutations have been identified in cancers of the brain, liver, ovary and large intestine, among others (reviewed in Polakis, 2000).
所含基因
14 个基因