CTNNB1 S45 突变体未磷酸化
中文名称
通路描述
β-catenin 的 S45 突变体已在结直肠癌、肝细胞癌、软组织癌和 Wilms 瘤等癌症中被鉴定 (综述于 Polakis, 2000)。这些突变消除了β-catenin 的 CK1α磷酸化位点，该位点是 GSK3 磷酸化 T41( 进而磷酸化 S37 和 S33) 的关键起始位点，从而防止其泛素介导的降解 (Morin et al, 1997; Amit et al, 2002)。
英文描述
CTNNB1 S45 mutants aren't phosphorylated S45 mutants of beta-catenin have been identified in colorectal and hepatocellular carcinomas, soft tissue cancer and Wilms Tumors, among others (reviewed in Polakis, 2000). These mutations abolish the CK1alpha phosphorylation site of beta-catenin which acts as a critical priming site for GSK3 phosphorylation of T41( and subsequently S37 and S33) thus preventing its ubiquitin-mediated degradation (Morin et al, 1997; Amit et al, 2002).
所含基因
14 个基因