TCF 依赖性信号转导的负调控
中文名称
通路描述
DVL 是 WNT 信号转导的核心组成部分，在经典和非经典通路中均发挥作用（综述：Gao 和 Chen, 2010）。在经典通路中，DVL 在 WNT 刺激下从破坏复合物中招募 AXIN，允许胞质β-猫enin积累（综述：MacDonald 等人，2009）。DVL 活性受磷酸化以及受调控的蛋白酶体或溶酶体降解调节（综述：Gao 和 Chen, 2010）。此外，DVL 活性还可通过与其他蛋白相互作用进行调控；CXXC4 和 CCDC88C 被鉴定为 WNT 信号转导的负调控因子，它们直接与 DVL 相互作用，尽管这些蛋白在限制 WNT 信号中的作用尚未完全阐明（Hino 等人，2001; Oshita 等人，2003; Ekici 等人，2010; Ishida-Takagishi 等人，2012）。
英文描述
Negative regulation of TCF-dependent signaling by DVL-interacting proteins DVL is a central component of WNT signaling that plays roles in both canonical and non-canonical pathways (reviewed in Gao and Chen, 2010). In the canonical pathway, DVL recruits AXIN from the destruction complex upon WNT stimulation, allowing cytosolic beta-catenin to accumulate (reviewed in MacDonald et al, 2009). DVL activity is regulated by phosphorylation as well as by regulated proteasomal or lysosomal degradation (reviewed in Gao and Chen, 2010). In addition, DVL activity can be regulated by interaction with other proteins; both CXXC4 and CCDC88C were identified as negative regulators of WNT signaling that interact directly with DVL, although the role of these proteins in limiting WNT signaling remain to be fully worked out (Hino et al, 2001; Oshita et al, 2003; Ekici et al, 2010; Ishida-Takagishi et al, 2012).
所含基因
5 个基因