甘氨酸降解
中文名称
通路描述
甘氨酸是最简单的氨基酸，通过多种降解途径被代谢。主要途径是通过甘氨酸裂解系统，包括二聚体P蛋白（GLDC）、T蛋白（AMT、GCST）、二聚体L蛋白（DLD）和H蛋白（GCSH）（Kikuchi et al. 2008）。
英文描述
APC truncation mutants have impaired AXIN binding Mutations in the APC tumor suppressor gene are common in colorectal and other cancers and cluster in the central mutation cluster region (MCR) of the gene (Miyoshi et al, 1992; Nagase and Nakamura, 1993; Dihlmann et al, 1999; reviewed in Bienz and Clevers, 2000). These mutations generally result in truncated proteins that destabilize the destruction complex and result in elevated WNT pathway activation (reviewed in Polakis, 2000).
所含基因
13 个基因