AXIN 错义突变破坏破坏复合物
中文名称
通路描述
AXIN1 的变异在多种癌症中已被检测到，包括肝癌和结直肠癌以及髓内胚细胞瘤等（综述见 Salahshor 和 Woodgett, 2005）。错义和无义突变会破坏或去除蛋白质 - 蛋白质相互作用结构域，AXIN 变异在癌症中倾向于破坏功能性破坏复合物的形成（Satoh 等，2000; Taniguchi 等，2002; Webster 等，2000; Shimizu 等，2002）。
英文描述
AXIN missense mutants destabilize the destruction complex Alterations in AXIN1 have been detected in a number of different cancers including liver and colorectal cancer and medullablastoma, among others (reviewed in Salahshor and Woodgett, 2005). Missense and nonsense mutations that disrupt or remove protein-protein interaction domains are common, and AXIN variants in cancers tend to disrupt the formation of a functional destruction complex (Satoh et al, 2000; Taniguchi et al, 2002; Webster et al, 2000; Shimizu et al, 2002).
所含基因
13 个基因