第 0 期 - 快速去极化
中文名称
通路描述
第 0 期是细胞动作电位中快速去极化期，在此期，电刺激引发涉及离子流入和流出事件的细胞事件，产生细胞动作电位。细胞的兴奋使关闭的快速 Na+ 通道蛋白开放，导致大量 Na+ 内流，产生 Na+ 电流（INa+）。这导致细胞去极化，然后电压依赖性 L 型钙通道（LTCCs）将 Ca2+ 转运到兴奋细胞。第 0 期的斜率代表电位变化的最大速率，并在收缩细胞和起搏细胞中有所不同。此期的电位从约 -90mV 变化到约 +50mV（Park & Fishman 2011, Grant 2009）。
英文描述
Phase 0 - rapid depolarisation Phase 0 is the rapid depolarisation phase in which electrical stimulation of a cell initiates events involving the influx and efflux of ions resulting in the production of a cell's action potential. The cell's excitation opens the closed, fast Na+ channel proteins, causing a large influx of Na+ creating a Na+ current (INa+). This causes depolarisation of the cell then voltage-dependent L-type calcium channels (LTCCs) transport Ca2+ into excitable cells. The slope of phase 0 represents the maximum rate of potential change and differs in contractile and pacemaker cells. The potential in this phase changes from around -90mV to around +50mV (Park & Fishman 2011, Grant 2009).
所含基因
32 个基因