CDH11 功能调节
中文名称
通路描述
CDH11 通过其胞内域与多种钙黏蛋白（如 CTNND1、CTNNB1、JUP 和 CTNNA1）结合，参与粘附连接子的建立与调节。此外，CDH11 的 C 端可与 AMOT-2 形成复合物，影响细胞迁移和肿瘤侵袭。通过其胞外区域，CDH11 与 ANGPTL4 的 C 端片段（cANGPTL4）结合，参与伤口愈合的调节。CDH11v 可通过竞争结合 cANGPTL4 来调节相关过程。
英文描述
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 PKN1, activated by phosphorylation at threonine T774, binds activated AR (androgen receptor) and promotes transcription from AR-regulated promoters. On one hand, phosphorylated PKN1 promotes the formation of a functional complex of AR with the transcriptional coactivator NCOA2 (TIF2) (Metzger et al. 2003). On the other hand, binding of phosphorylated PKN1, in complex with the activated AR, to androgen-reponsive promoters of KLK2 and KLK3 (PSA) genes, leads to PKN1-mediated histone phosphorylation. PKN1-phosphorylated histones recruit histone demethylases KDM4C (JMJD2C) and KDM1A (LSD1), and the ensuing demethylation of histones associated with the promoter regions of KLK2 and KLK3 genes increases their transcription (Metzger et al. 2005, Metzger et al. 2008).
所含基因
35 个基因