FoxO信号通路
中文名称
通路描述
forkhead box O (FOXO)转录因子家族调节细胞生理事件中的基因表达，包括凋亡、细胞周期控制、葡萄糖代谢、氧化应激抵抗和长寿。FOXO蛋白的中心调控机制是磷酸化，由丝氨酸 - 苏氨酸激酶Akt/蛋白激酶B（Akt/PKB）介导，Akt/PKB位于磷脂酰肌醇3-激酶（PI3K）下游，在胰岛素或多种生长因子的刺激下发生。磷酸化发生在三个保守残基上，导致FOXO蛋白从细胞核转运至细胞质，从而降低FOXO靶基因的转录。相比之下，应激激活的c-Jun N-末端激酶（JNK）和能量感应AMP激活蛋白激酶（AMPK）在氧化和营养应激刺激下磷酸化并激活FOXO。除了PKB、JNK和AMPK外，FOXO蛋白还通过多种翻译后修饰（包括磷酸化、乙酰化、甲基化和泛素化）受多个调节因子调控。
英文描述
Phospholipase C-mediated cascade: FGFR1 Phospholipase C-gamma (PLC-gamma) is a substrate of the fibroblast growth factor receptor (FGFR) and other receptors with tyrosine kinase activity. It is known that the src homology region 2 (SH2 domain) of PLC-gamma and of other signaling molecules (such as GTPase-activating protein and phosphatidylinositol 3-kinase-associated p85) direct their binding toward autophosphorylated tyrosine residues of the FGFR. Recruitment of PLC-gamma results in its phosphorylation and activation by the receptor. Activated PLC-gamma hydrolyzes phosphatidyl inositol[4,5] P2 to form the second messengers diacylglycerol (DAG) and Ins [1,4,5]P3, which stimulate calcium release and activation of calcium/calmodulin dependent kinases.
所含基因
12 个基因