磷脂酶 C 介导的级联反应; FGFR3
中文名称
通路描述
磷脂酶 C-gamma (PLC-gamma) 是成纤维细胞生长因子受体 (FGFR) 和其他具有酪氨酸激酶活性的受体的底物。已知 PLC-gamma 的 src 同源结构域 2 (SH2 结构域) 和其他信号分子 (如 GTP 酶激活蛋白和磷脂酰肌醇 3-激酶辅助 p85) 将其结合导向 FGFR 的自磷酸化酪氨酸残基。PLC-gamma 的招募导致其受体介导的磷酸化和激活。活化的 PLC-gamma 水解磷脂酰肌醇 [4,5]P2 形成第二信使二酰甘油 (DAG) 和 Ins [1,4,5]P3，后者刺激钙释放和钙/钙调蛋白依赖性激酶的激活。
英文描述
Phospholipase C-mediated cascade; FGFR3 Phospholipase C-gamma (PLC-gamma) is a substrate of the fibroblast growth factor receptor (FGFR) and other receptors with tyrosine kinase activity. It is known that the src homology region 2 (SH2 domain) of PLC-gamma and of other signaling molecules (such as GTPase-activating protein and phosphatidylinositol 3-kinase-associated p85) direct their binding toward autophosphorylated tyrosine residues of the FGFR. Recruitment of PLC-gamma results in its phosphorylation and activation by the receptor. Activated PLC-gamma hydrolyzes phosphatidyl inositol[4,5] P2 to form the second messengers diacylglycerol (DAG) and Ins [1,4,5]P3, which stimulate calcium release and activation of calcium/calmodulin dependent kinases.
所含基因
9 个基因