SHC级联：FGFR2
中文名称
通路描述
SHC1在FGFR信号传导中的确切作用尚不清楚。多项研究表明，在FGF刺激下，SHC1的p46和p52等位基因会发生磷酸化，但尚未证明其与受体的直接相互作用。据报道，p46和p52与FGFR2 IIIc受体的共沉淀，但这种相互作用被认为是间接的，可能由SRC介导。与这一观点一致，在表达v-SRC的哺乳动物细胞中观察到SHC1和FGFR1 IIIc的共沉淀。SHC1的p66等位基因也与FGFR3共沉淀，但这是在受体刺激独立发生的，且p66等位基因尚未显示受FGF依赖性磷酸化。SHC1已被证明与GRB2和SOS1结合，以响应FGF刺激，表明SHC1的招募可能有助于FGFR下游MAP激酶通路的激活。
英文描述
SHC-mediated cascade:FGFR2 The exact role of SHC1 in FGFR signaling remains unclear. Numerous studies have shown that the p46 and p52 isoforms of SHC1 are phosphorylated in response to FGF stimulation, but direct interaction with the receptor has not been demonstrated. Co-precipitation of p46 and p52 with the FGFR2 IIIc receptor has been reported, but this interaction is thought to be indirect, possibly mediated by SRC. Consistent with this, co-precipitation of SHC1 and FGFR1 IIIc is seen in mammalian cells expressing v-SRC. The p66 isoform of SHC1 has also been co-precipitated with FGFR3, but this occurs independently of receptor stimulation, and the p66 isoform not been shown to undergo FGF-dependent phosphorylation. SHC1 has been shown to associate with GRB2 and SOS1 in response to FGF stimulation, suggesting that the recruitment of SHC1 may contribute to activation of the MAPK cascade downstream of FGFR.
所含基因
14 个基因