PI-3K激酶级联反应：FGFR3
中文名称
通路描述
生长因子保护细胞免受凋亡的主要机制是激活AKT生存通路。PDK依赖的PI-3K激活导致AKT激活，进而影响促凋亡因子的活性或表达，从而保护细胞免受凋亡。AKT的激活还能抑制GSK-3b的活性，从而产生额外的抗凋亡信号。
英文描述
PI-3K cascade:FGFR3 The ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which in turn affects the activity or expression of pro-apoptotic factors, which contribute to protection from apoptosis. AKT activation also blocks the activity of GSK-3b which could lead to additional antiapoptotic signals.
所含基因
13 个基因