FRS介导的FGFR4信号通路
中文名称
通路描述
FRS家族支架适配蛋白有两个成员，即FRS2（也称为FRS2α）和FRS3（也称为FRS2β或SNT-2）。FGFR酪氨酸激酶的激活使FRS蛋白在酪氨酸残基上发生磷酸化，然后与适配蛋白GRB2和酪氨酸磷酸酶PPTN11/SHP2结合。随后，PPTN11激活RAS-MAP激酶通路，GRB2通过SH3结构域与SOS、GAB1和CBL结合，激活RAS-MAP激酶、PI-3激酶和泛素化/降解通路。FRS2在FGF信号传导中起核心调节作用，主要是因为其诱导持续的ERK激活，且表达广泛。
英文描述
FRS-mediated FGFR4 signaling The FRS family of scaffolding adaptor proteins has two members, FRS2 (also known as FRS2 alpha) and FRS3 (also known as FRS2beta or SNT-2). Activation of FGFR tyrosine kinase allows FRS proteins to become phosphorylated on tyrosine residues and then bind to the adaptor GRB2 and the tyrosine phosphatase PPTN11/SHP2. Subsequently, PPTN11 activates the RAS-MAP kinase pathway and GRB2 activates the RAS-MAP kinase , PI-3-kinase and ubiquitinations/degradation pathways by binding to SOS, GAB1 and CBL, respectively, via the SH3 domains of GRB2. FRS2 acts as a central mediator in FGF signaling mainly because it induces sustained levels of activation of ERK with ubiquitous expression.
所含基因
16 个基因