SHC介导的FGFR4级联反应
中文名称
通路描述
SHC1在FGFR信号传导中的确切作用尚不清楚。多项研究表明，在FGF刺激下，SHC1的p46和p52异构体会发生磷酸化，但尚未证明其直接与受体相互作用。据报道，p46和p52与FGFR2 IIIc受体共沉淀，但这种相互作用被认为是间接的，可能由SRC介导。与这一观点一致，在表达v-SRC的哺乳动物细胞中，SHC1与FGFR1 IIIc共沉淀。SHC1的p66异构体也与FGFR3共沉淀，但这是在受体刺激独立发生的，且p66异构体尚未显示出FGF依赖性磷酸化。SHC1已被证明与GRB2和SOS1结合，以FGF刺激为响应，这表明SHC1的招募可能有助于FGFR下游MAPK级联反应的激活。
英文描述
SHC-mediated cascade:FGFR4 The exact role of SHC1 in FGFR signaling remains unclear. Numerous studies have shown that the p46 and p52 isoforms of SHC1 are phosphorylated in response to FGF stimulation, but direct interaction with the receptor has not been demonstrated. Co-precipitation of p46 and p52 with the FGFR2 IIIc receptor has been reported, but this interaction is thought to be indirect, possibly mediated by SRC. Consistent with this, co-precipitation of SHC1 and FGFR1 IIIc is seen in mammalian cells expressing v-SRC. The p66 isoform of SHC1 has also been co-precipitated with FGFR3, but this occurs independently of receptor stimulation, and the p66 isoform not been shown to undergo FGF-dependent phosphorylation. SHC1 has been shown to associate with GRB2 and SOS1 in response to FGF stimulation, suggesting that the recruitment of SHC1 may contribute to activation of the MAPK cascade downstream of FGFR.
所含基因
13 个基因