FGFR3信号通路的负调控
中文名称
通路描述
一旦激活，FGFR信号通路通过多种负反馈机制进行调控。这些机制包括通过CBL介导的泛素化和内吞作用下调受体、ERK介导的FRS2酪氨酸磷酸化抑制以及通过双特异性磷酸酶、IL17RD/SEF、Sprouty和Spred蛋白的作用减弱ERK信号。其中许多抑制剂本身也是激活的FGFR通路的转录靶点。
英文描述
Negative regulation of FGFR3 signaling Once activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-mediated inhibition of FRS2-tyrosine phosphorylation and the attenuation of ERK signaling through the action of dual-specificity phosphatases, IL17RD/SEF, Sprouty and Spred proteins. A number of these inhibitors are themselves transcriptional targets of the activated FGFR pathway.
所含基因
17 个基因