Mucin type O-glycan biosynthesis
中文名称
通路描述
O-糖链是一类修饰蛋白质丝氨酸或苏氨酸残基的糖链。O-糖链的生物合成始于N-乙酰半乳糖胺（GalNAc）向丝氨酸或苏氨酸的转移。第一个GalNAc可进一步延伸，包括半乳糖、N-乙酰葡萄糖胺、fucose或唾液酸，但不能是甘露糖、葡萄糖或木糖。根据添加的糖不同，存在四种常见的O-糖链核心结构（核心1至4）以及另外四种核心结构（核心5至8）。黏蛋白是高度O-糖基化的糖蛋白，广泛存在于细胞表面的黏液分泌和体液中。黏蛋白O-糖链可以是分支的，许多糖或糖组具有抗原性。黏蛋白O-糖链的重要修饰包括唾液酸的O-乙酰化和半乳糖及N-乙酰葡萄糖胺的O-硫酸化。
英文描述
Translesion synthesis by POLK DNA polymerase kappa (POLK) is a Y family DNA polymerase that is most efficient in translesion DNA synthesis (TLS) across oxidation derivatives of DNA bases, such as thymine glycol (Tg) and 8-oxoguanine (OGUA), as well as bulky DNA adducts, such as benzo(a)pyrene diol epoxide guanine adduct (BPDE-G) (Zhang et al. 2000, Fischhaber et al.2002, Avkin et al. 2004, Vasquez-Del Carpio et al. 2009, Yoon et al. 2010, Lior-Hoffmann et al. 2012, Christov et al. 2012, Yoon et al. 2014). POLK carries out TLS by forming a quaternary complex with REV1 and POLZ (REV3L:MAD2L2) at DNA damage sites, where POLK simultaneously binds REV1 and monoubiquitinated PCNA (Ohashi et al. 2009, Haracska, Unk et al. 2002, Bi et al. 2006). POLK and POLZ cooperate in the elongation of nucleotides inserted opposite to lesioned bases by POLK. Similarly to POLZ, POLK has low processivity and is error-prone (Ohashi et al. 2000, Haracska, Prakash et al. 2002, Yoon et al. 2010).
所含基因
17 个基因