跨损伤DNA合成的终止
中文名称
通路描述
跨损伤DNA合成（TLS）的起始和程度必须受到严格控制，以限制由TLS参与DNA聚合酶的低保真度引起的TLS诱发的突变。由于PCNA在赖氨酸残基K164处的单泛素化是TLS复合物在受损DNA模板上组装的先决条件，PCNA去泛素化是TLS终止的关键步骤，允许DNA聚合酶从参与TLS的Y家族DNA聚合酶切换到δ和ε复制DNA聚合酶（Povlsen et al. 2012, Park et al. 2014）。
英文描述
Termination of translesion DNA synthesis The initiation and extent of translesion DNA synthesis (TLS) has to be tightly controlled in order to limit TLS-induced mutagenesis, caused by the low fidelity of TLS-participating DNA polymerases. Since monoubiquitination of PCNA at lysine residue K164 is a prerequisite for the assembly of TLS complexes on damaged DNA templates, PCNA deubiquitination is a key step in TLS termination that allows DNA polymerase switching from Y family DNA polymerases involved in TLS to replicative DNA polymerases delta and epsilon (Povlsen et al. 2012, Park et al. 2014).
所含基因
32 个基因