MGMT介导的DNA损伤逆转
中文名称
通路描述
活性细胞代谢物可通过对鸟嘌呤进行6-O-甲基化引起DNA损伤。6-O-甲基鸟嘌呤可与C和T发生错配，导致转换突变。MGMT是一种具有6-O-甲基鸟嘌呤-DNA甲基转移酶活性的蛋白质，可促进此类损伤的逆转（Mitra and Kaina 1993）。
英文描述
MGMT-mediated DNA damage reversal Reactive cellular catabolites can cause DNA damage by 6-O-methylation of guanine. 6-O-methylguanine can pair ambiguously with both C and T, and cause transition mutations. Active reversal of such damage can be facilitated by MGMT, a protein that has 6-O-methylguanine-DNA methyltransferase activity (Mitra and Kaina 1993).
所含基因
1 个基因