FGFRL1 对 FGFR1 信号通路的调节
中文名称
通路描述
FGFRL1 是 FGFR 受体家族中的第五个成员。其胞外区域与 FGFR1-4 具有 40% 的同源性，但 FGFRL1 缺乏其他 FGF 受体的内部激酶结构域，其在 FGFR 信号传导中的作用尚不清楚。一些模型认为 FGFRL1 通过捕获配体远离激酶活性受体来限制经典 FGFR 信号传导，而其他模型则认为 FGFRL1 可能通过聚集信号复合物或增强 ERK1/2 激活来促进经典信号传导（参见 Trueb, 2011; Trueb et al, 2013）。
英文描述
FGFRL1 modulation of FGFR1 signaling FGFRL1 is a fifth member of the FGFR family of receptors. The extracellular region has 40% sequence similarity with FGFR1-4, but FGFRL1 lacks the internal kinase domain of the other FGF receptors and how it acts in FGFR signaling is unclear. Some models suggest FGFRL1 restricts canonical FGFR signaling by sequestering ligand away from kinase-active receptors, while other models suggest that FGFRL1 may promote canonical signaling by nucleating signaling complexes or enhancing ERK1/2 activation (reviewed in Trueb, 2011; Trueb et al, 2013).
所含基因
10 个基因