MTF1 激活基因表达
中文名称
通路描述
核内的 MTF1:锌复合物结合金属反应元件（MRE），该 DNA 包含核心共识序列 5'-TGCRCNC-3'，并根据 MRE 的上下文激活或抑制转录（参见 Laity and Andrews 2007, Jackson et al. 2008, Gunther et al. 2012, Grzywacz et al. 2015）。每个 MTF1 单体有 6 个锌指，对锌的亲和力不同，来自小鼠同源物的证据表明，不同浓度的锌（即 MTF1 中不同的金属负载）会激活不同的靶基因子集（Wang et al. 2004, Dong et al. 2015）。MTF1 激活的基因包括编码金属lothioneins、锌转运蛋白和应激反应蛋白的基因（Hardyman et al. 2016）。
英文描述
MTF1 activates gene expression The MTF1:zinc complex in the nucleus binds Metal Response Elements (MREs), DNA containing the core consensus sequence 5'-TGCRCNC-3', and activates or represses transcription depending on the context of the MRE (reviewed in Laity and Andrews 2007, Jackson et al. 2008, Gunther et al. 2012, Grzywacz et al. 2015). The 6 zinc fingers of each MTF1 monomer have different affinities for zinc and evidence from the mouse homolog indicates that different concentrations of zinc, and hence different metal loads in MTF1, activate different subsets of target genes (Wang et al. 2004, Dong et al. 2015). Genes activated by MTF1 include those encoding metallothioneins, zinc transporters, and stress-response proteins (Hardyman et al. 2016).
所含基因
3 个基因