体内RCbl的运输
中文名称
通路描述
此处注释了钴胺素（RCbl）从肠细胞到发挥辅酶作用的细胞中的运输步骤，以及其在肾小管的重吸收。虽然甲基钴胺素是血液中的主要钴胺素（Chu et al. 1993），但氰钴胺素和腺苷钴胺素等其他钴胺素也存在，参与这些过程的蛋白质可容纳所有它们（Banerjee et al. 2021; Nielsen et al. 2012; Quadros 2010）。这种广泛的特异性由注释所有此类过程的RCbl（R-cob(III)alamin，CHEBI:140785）来指示。
英文描述
MAP2K and MAPK activation Activated RAF proteins are restricted substrate kinases whose primary downstream targets are the two MAP2K proteins, MAPK2K1 and MAP2K2 (also known as MEK1 and MEK2) (reviewed in Roskoski, 2010, Roskoski, 2012a). Phosphorylation of the MAPK2K activation loop primes them to phosphorylate the primary effector of the activated MAPK pathway, the two MAPK proteins MAPK3 and MAPK1 (also known as ERK1 and 2). Unlike their upstream counterparts, MAPK3 and MAPK1 catalyze the phosphorylation of hundreds of cytoplasmic and nuclear targets including transcription factors and regulatory molecules (reviewed in Roskoski, 2012b). Activation of MAP2K and MAPK proteins downstream of activated RAF generally occurs in the context of a higher order scaffolding complex that regulates the specificity and localization of the pathway (reviewed in Brown and Sacks, 2009; Matallanas et al, 2011).
所含基因
35 个基因