RHO GTPases 激活 IQGAPs
中文名称
通路描述
IQGAPs 是一类由钙连同源结构域（CH 域）、多脯氨酸结合结构域（WW 域）、四个 IQ 重复序列以及 RAS GTPase 激活蛋白相关结构域（GRD）组成的支架蛋白家族。人类中已鉴定出 IQGAP1、IQGAP2 和 IQGAP3 三种。IQGAP1 是研究最深入的，有超过 90 种蛋白质与其结合。IQGAPs 整合多种信号通路并协调多种细胞活动。IQGAP1、IQGAP2 和 IQGAP3 通过 GRD 与激活的 RHO GTPase（RAC1 和 CDC42）结合，稳定其 GTP 结合状态。IQGAPs 通过 CH 域与 F-actin 丝结合，并通过调节 G-actin/F-actin 平衡来调控细胞形状和运动性。IQGAPs 与 F-actin 的结合受到钙调蛋白结合到 IQ 重复序列的抑制。基于 IQGAP1 的研究，IQGAPs 可能以同源二聚体形式发挥作用。IQGAP1 通过与 E-cadherin（CDH1）和连接蛋白（CTTNB1 和 CTTNA1）相互作用，参与粘附连接体的调节。IQGAP1 通过与微管相互作用，参与细胞极性和片状伪足的形成。
英文描述
NIK-->noncanonical NF-kB signaling In addition to the activation of canonical NF-kB subunits, activation of SYK pathway by Dectin-1 leads to the induction of the non-canonical NF-kB pathway, which mediates the nuclear translocation of RELB-p52 dimers through the successive activation of NF-kB-inducing kinase (NIK) and IkB kinase-alpha (IKKa) (Geijtenbeek & Gringhuis 2009, Gringhuis et al. 2009). Noncanonical activity tends to build more slowly and remain sustained several hours longer than does the activation of canonical NF-kB. The noncanonical NF-kB pathway is characterized by the post-translational processing of NFKB2 (Nuclear factor NF-kappa-B) p100 subunit to the mature p52 subunit. This subsequently leads to nuclear translocation of p52:RELB (Transcription factor RelB) complexes to induce cytokine expression of some genes (C-C motif chemokine 17 (CCL17) and CCL22) and transcriptional repression of others (IL12B) (Gringhuis et al. 2009, Geijtenbeek & Gringhuis 2009, Plato et al. 2013).
所含基因
45 个基因