LGI-ADAM 相互作用
中文名称
通路描述
突触的形成和成熟需要突触前神经元和突触后神经元之间的多种相互作用。这些相互作用由多种突触生成蛋白介导（Kegel 等人，2013；Siddiqui 和 Craig 等人，2011）。突触形成的初始阶段需要分泌蛋白与突触前和突触后受体的结合，以及突触前和突触后跨膜蛋白的直接结合。一类在神经系统发育和功能细胞相互作用中发挥重要作用的分子是线粒体富集蛋白（LGI）蛋白家族。这些是分泌的突触生成蛋白，由富含亮氨酸重复结构域（LRR）和癫痫相关或 EPTP（epitempin）结构域组成（Gu 等人，2002）。这两个蛋白结构域通常都参与蛋白质 - 蛋白质相互作用。遗传和生化证据表明，LGI 蛋白的作用机制涉及与 ADAM（解聚素和金属蛋白酶）家族中某些细胞表面受体的结合，即 ADAM11、ADAM22 和 ADAM23。这些相互作用在脊椎动物神经系统的发育和功能中起关键作用，主要通过介导突触传递和髓鞘化（Kegel 等人，2013；Novak 等人，2004；Seals 和 Courtneidge 等人，2003）。
英文描述
LGI-ADAM interactions Synapse formation and maturation require multiple interactions between presynaptic and postsynaptic neurons. These interactions are mediated by a diverse set of synaptogenic proteins (Kegel et al. 2013, Siddiqui & Craig 2011). Initial synapse formation needs both the binding of secreted proteins to presynaptic and postsynaptic receptors, and the direct binding between presynaptic and postsynaptic transmembrane proteins. One class of molecules that plays an important role in cellular interactions in nervous system development and function is the leucine-rich glioma inactivated (LGI) protein family. These are secreted synaptogenic proteins consisting of an LRR (leucine-rich repeat) domain and a epilepsy-associated or EPTP (epitempin) domain (Gu et al. 2002). Both protein domains are generally involved in protein-protein interactions. Genetic and biochemical evidence suggests that the mechanism of action of LGI proteins involves binding to a subset of cell surface receptors belonging to the ADAM (a disintegrin and metalloproteinase) family, i.e. ADAM11, ADAM22 and ADAM23. These interactions play crucial role in the development and function of the vertebrate nervous system mainly mediating synaptic transmission and myelination (Kegel et al. 2013, Novak 2004, Seals & Courtneidge 2003).
所含基因
14 个基因