Josephin 结构域 DUB
中文名称
通路描述
Josephin 结构域存在于四种人类 DUB 中：Ataxin-3 (ATXN3), ATXN3L, Josephin-1 (JOSD1) 和 JOSD2。所有都已被证明具有 DUB 活性 (Tzveltkov & Breuer 2007, Weeks et al. 2011)。Josephin 结构域 DUB 可能专门化在区分不同长度的多 Ub 链之间 (Eletr & Wilkinson 2014)。
英文描述
Josephin domain DUBs The Josephin domain is present in four human DUBs: Ataxin-3 (ATXN3), ATXN3L, Josephin-1 (JOSD1) and JOSD2. All have been shown to possess DUB activity (Tzveltkov & Breuer 2007, Weeks et al. 2011). Josephin domain DUBs may specialize in distinguishing between polyubiquitin chains of different lengths (Eletr & Wilkinson 2014).
所含基因
12 个基因