卵巢肿瘤域蛋白酶
中文名称
通路描述
人类拥有 16 种卵巢肿瘤域（OTU）家族 DUB，可进化分为三类：OTU、OTUB 和 A20 样 OTU（Komander 等，2009）。OTU 家族 DUB 在切割的泛素交联类型上具有高度选择性。OTUB1 特异性切割 K48 交联链，而 OTUB2 可切割 K11、K63 和 K48 交联的多聚泛素（Wang 等，2009；Edelmann 等，2009；Mevissen 等，2013）。A20 偏好 K48 交联链，Cezanne 特异性切割 K11 交联链，TRABID 作用于 K29、K33 和 K63 交联的多聚泛素（Licchesi 等，2011；Komander 和 Barford，2008；Bremm 等，2010；Mevissen 等，2013）。OTU 域活性位点包含一种在其他丝氨酸 - 二肽泛素化酶（thiol-DUBs）中未见的异常环，且可能缺乏明显的催化 Asp/Asn（Komander 和 Barford，2009；Messick 等，2008；Lin 等，2008）。A20 和 OTUB1 具有独特的活性模式，直接结合 E2 酶（Nakada 等，2010；Wertz 等，2004）。
英文描述
Ovarian tumor domain proteases Humans have 16 Ovarian tumour domain (OTU) family DUBs that can be evolutionally divided into three classes, the OTUs, the Otubains (OTUBs), and the A20-like OTUs (Komander et al. 2009).
OTU family DUBs can be highly selective in the type of ubiquitin crosslinks they cleave. OTUB1 is specific for K48-linked chains, whereas OTUB2 can cleave K11, K63 and K48-linked poly-Ub (Wang et al. 2009, Edelmann et al. 2009, Mevissen et al. 2013). A20 prefers K48-linked chains, Cezanne is specific for K11-linked chains, and TRABID acts on both K29, K33 and K63-linked poly-Ub (Licchesi et al. 2011, Komander & Barford 2008, Bremm et al. 2010, Mevissen et al. 2013). The active site of the OTU domain contains an unusual loop not seen in other thiol-DUBs and can lack an obvious catalytic Asp/Asn (Komander & Barford 2009, Messick et al. 2008, Lin et al. 2008). A20 and OTUB1 have an unusual mode of activity, binding directly to E2 enzymes (Nakada et al. 2010, Wertz et al. 2004).
OTU family DUBs can be highly selective in the type of ubiquitin crosslinks they cleave. OTUB1 is specific for K48-linked chains, whereas OTUB2 can cleave K11, K63 and K48-linked poly-Ub (Wang et al. 2009, Edelmann et al. 2009, Mevissen et al. 2013). A20 prefers K48-linked chains, Cezanne is specific for K11-linked chains, and TRABID acts on both K29, K33 and K63-linked poly-Ub (Licchesi et al. 2011, Komander & Barford 2008, Bremm et al. 2010, Mevissen et al. 2013). The active site of the OTU domain contains an unusual loop not seen in other thiol-DUBs and can lack an obvious catalytic Asp/Asn (Komander & Barford 2009, Messick et al. 2008, Lin et al. 2008). A20 and OTUB1 have an unusual mode of activity, binding directly to E2 enzymes (Nakada et al. 2010, Wertz et al. 2004).
所含基因
38 个基因