通过 Gbeta/gamma 亚基抑制电压门控钙通道
中文名称
通路描述
GABA B 受体与 G 蛋白偶联，通过增加 K+ 和减少细胞内的 Ca2+ 发挥作用。K+ 的增加增加了细胞的膜电位负值，导致细胞超极化，从而抑制神经递质的释放。Ca2+ 的减少通过两种方式抑制神经递质：首先通过阻止含有神经递质的突触小泡与质膜的融合，其次通过减少 Ca2+ 依赖的突触小泡向质膜招募。特别是 GABA B 受体通过 G 蛋白 Gbeta/Ggamma 亚基的活动抑制电压门控钙通道。
英文描述
Metalloprotease DUBs The JAB1/MPN +/MOV34 (JAMM) domain metalloproteases cleave the isopeptide bond at or near the the attachment point of polyubiquitin and substrate. PSMD14 (RPN11), STAMBP (AMSH), STAMBPL1 (AMSH-LP), and BRCC3 (BRCC36) are highly specific for the K63 poly-Ub linkage, which may be a general characteristic (Eletr & Wilkinson 2014). Two multisubunit complexes represented elsewhere in Reactome contain JAMM DUBs. The proteasome 19S lid complex includes PSMD14, an endopeptidase that cleaves poly-Ub chains from substrates as they are degraded by the proteasome (Verma et al. 2002). The COP9-Signalosome contains COPS5 (CSN5), which deconjugates the Ub-like modifier Nedd8, modulating the activity of the SCF E3 ligase (Cope et al. 2002).
JAMM DUB catalysis requires nucleophilic attack on the carbonyl carbon of the isopeptide bond by an activated water molecule bound to Zn2+ and a conserved glutamate. A negatively-charged tetrahedral transition state ensues, and a nearby conserved Ser/Thr in the JAMM domains stabilizes the oxyanion. The tetrahedral intermediate then collapses and the Glu serves as a general base donating a proton to the leaving Lys side chain (Ambroggio et al. 2004).
JAMM DUB catalysis requires nucleophilic attack on the carbonyl carbon of the isopeptide bond by an activated water molecule bound to Zn2+ and a conserved glutamate. A negatively-charged tetrahedral transition state ensues, and a nearby conserved Ser/Thr in the JAMM domains stabilizes the oxyanion. The tetrahedral intermediate then collapses and the Glu serves as a general base donating a proton to the leaving Lys side chain (Ambroggio et al. 2004).
所含基因
31 个基因