杂项底物
中文名称
通路描述
大约四分之一的 57 种人类 CYP 酶仍被视为‘孤儿’，即其功能、表达位点和调控机制尚未阐明。尽管已有足够的实验证据表明这些蛋白质均被合成并在体外催化 CYP 类反应，但缺乏体内功能及底物特异性的证据，因此无法将其归类于功能方案中的任何一类。
英文描述
Sensing of DNA Double Strand Breaks Detection of DNA double-strand breaks (DSBs) involves sensor proteins of the MRN complex, composed of MRE11A, RAD50 and NBN (NBS1). Binding of the MRN complex to DNA DSBs activates ATM-dependent DNA damage signaling cascade, by promoting KAT5 (Tip60) mediated acetylation of ATM and subsequent ATM autophosphorylation. Activated ATM triggers and coordinates recruitment of repair proteins to DNA DSBs (Beamish et al. 2002, Thompson and Schild 2002, Bakkenist et al. 2003, Lee and Paull 2005, Sun et al. 2005, Sun et al. 2007, Ciccia and Elledge 2010).
所含基因
6 个基因