同源 DNA 配对和链交换的前突期
中文名称
通路描述
同源重组修复（HRR）中的同源 DNA 配对和链交换的前突期始于 RPA 从单链 DNA（ssDNA）的置换，由 RAD51 和 BRCA2 共同作用完成（Thompson and Limoli 2003）。CHEK1 介导的 RAD51 和 BRCA2 磷酸化（Sorensen et al. 2005, Bahassi et al. 2008）对于 BRCA2 介导的 RAD51 在 3'-ssDNA 突出端上的核化、RPA 置换以及 RAD51 核丝的形成是必需的（Yang et al. 2005, Jensen et al. 2010, Liu et al. 2010, Thorslund et al. 2010）。侵入性的 RAD51 核丝由 RAD51B、RAD51C、RAD51D 和 XRCC2 组成的 BCDX2 复合物稳定（Masson et al. 2001, Chun et al. 2013, Amunugama et al. 2013）。
英文描述
Presynaptic phase of homologous DNA pairing and strand exchange The presynaptic phase of homologous DNA pairing and strand exchange during homologous recombination repair (HRR) begins with the displacement of RPA from ssDNA (Thompson and Limoli 2003) by the joint action of RAD51 and BRCA2. CHEK1-mediated phosphorylation of RAD51 and BRCA2 (Sorensen et al. 2005, Bahassi et al. 2008) is needed for BRCA2-mediated nucleation of RAD51 on 3'-ssDNA overhangs, RPA displacement and formation of RAD51 nucleofilaments (Yang et al. 2005, Jensen et al. 2010, Liu et al. 2010, Thorslund et al. 2010). Invasive RAD51 nucleofilaments are stabilized by the BCDX2 complex composed of RAD51B, RAD51C, RAD51D and XRCC2 (Masson et al. 2001, Chun et al. 2013, Amunugama et al. 2013).
所含基因
39 个基因