GG-NER 中的 DNA 损伤识别
中文名称
通路描述
在全基因组核苷酸切除修复（GG-NER）中，DNA 损伤由两个蛋白质复合物识别。第一个复合物由 XPC、RAD23A 或 RAD23B 和 CETN2 组成。该复合物探针 DNA 双螺旋，识别破坏正常 Watson-Crick 碱基配对的损伤，导致 XPC:RAD23:CETN2 复合物结合到未受损的 DNA 链上。第二个复合物是泛素连接酶 UV-DDB，由 DDB2、DDB1、CUL4A 或 CUL4B 和 RBX1 组成。UV-DDB 复合物对于识别紫外线诱导的 DNA 损伤是必需的，并可能有助于将 XPC:RAD23:CETN2 复合物保留在 DNA 损伤位点。UV-DDB 复合物结合受损的 DNA 链（Fitch et al. 2003, Wang et al. 2004, Moser et al. 2005, Camenisch et al. 2009, Oh et al. 2011）。
英文描述
DNA Damage Recognition in GG-NER In global genome nucleotide excision repair (GG-NER), the DNA damage is recognized by two protein complexes. The first complex consists of XPC, RAD23A or RAD23B, and CETN2. This complex probes the DNA helix and recognizes damage that disrupts normal Watson-Crick base pairing, which results in binding of the XPC:RAD23:CETN2 complex to the undamaged DNA strand. The second complex is a ubiquitin ligase UV-DDB that consists of DDB2, DDB1, CUL4A or CUL4B and RBX1. The UV-DDB complex is necessary for the recognition of UV-induced DNA damage and may contribute to the retention of the XPC:RAD23:CETN2 complex at the DNA damage site. The UV-DDB complex binds the damaged DNA strand (Fitch et al. 2003, Wang et al. 2004, Moser et al. 2005, Camenisch et al. 2009, Oh et al. 2011).
所含基因
39 个基因