GG-NER 中的缺口填补 DNA 修复合成和连接
中文名称
通路描述
全基因组核苷酸切除修复（GG-NER）通过 DNA 修复合成完成，该合成填充了受损 DNA 链双切口后形成的单链缺口，并切除包含损伤的约 27-30 个碱基的寡核苷酸。DNA 合成由 DNA 聚合酶 epsilon 或 delta，或 Y 家族 DNA 聚合酶 kappa（POLK）执行，这些聚合酶在 5' 切口后装载到修复位点（Staresincic et al. 2009, Ogi et al. 2010）。DNA 连接酶 LIG1 或 LIG3 将新合成的寡核苷酸片段连接到切口 DNA 链上（Arakawa et al. 2012, Paul-Konietzko et al. 2015）。
英文描述
Gap-filling DNA repair synthesis and ligation in GG-NER Global genome nucleotide excision repair (GG-NER) is completed by DNA repair synthesis that fills the single stranded gap created after dual incision of the damaged DNA strand and excision of the ~27-30 bases long oligonucleotide that contains the lesion. DNA synthesis is performed by DNA polymerases epsilon or delta, or the Y family DNA polymerase kappa (POLK), which are loaded to the repair site after 5' incision (Staresincic et al. 2009, Ogi et al. 2010). DNA ligases LIG1 or LIG3 ligate the newly synthesized stretch of oligonucleotides to the incised DNA strand (Arakawa et al. 2012, Paul-Konietzko et al. 2015).
所含基因
25 个基因