抗菌蛋白的金属螯合
中文名称
通路描述
金属对于所有生命形式，包括微生物都是必需的，这一点由迄今为止结晶的蛋白质中金属阳离子约占 40% 的事实所证明（Waldron KJ 等人，2009；Foster AW 等人，2014；Guengerich FP 2014、2015）。微生物维持细胞内金属配额的能力对于适应各种环境至关重要。因此，宿主在炎症部位控制金属配额的能力可以影响宿主 - 病原体相互作用。宿主可以通过排除微生物所需的金属、向微生物提供过量金属以引起毒性，或通过螯合微生物中的金属来限制微生物生长。
英文描述
Metal sequestration by antimicrobial proteins Metals are necessary for all forms of life including microorganisms, evidenced by the fact that metal cations are constituents of approximately 40% of all proteins crystallized to date (Waldron KJ et al. 2009; Foster AW et al. 2014; Guengerich FP 2014, 2015). The ability of microorganisms to maintain the intracellular metal quota is essential and allows microorganisms to adapt to a variety of environments. Accordingly, the ability of the host to control metal quota at inflammation sites can influence host-pathogen interactions. The host may restrict microbial growth either by excluding essential metals from the microbes, by delivery of excess metals to cause toxicity, or by complexing metals in microorganisms (Becker KW & Skaar EP 2014).
所含基因
6 个基因