TP53 调控死亡受体和配体的转录
中文名称
通路描述
TP53 的促凋亡转录靶点包括 TRAIL 死亡受体 TNFRSF10A（DR4）、TNFRSF10B（DR5）、TNFRSF10C（DcR1）和 TNFRSF10D（DcR2），以及 FASL/CD95L 死亡受体 FAS（CD95）。TRAIL 受体和 FAS 通过外源性凋亡途径响应外部刺激诱导促凋亡信号。IGFBP3 是 TP53 的转录靶点，可能作为新型死亡受体 TMEM219 的配体。
英文描述
TP53 Regulates Transcription of Death Receptors and Ligands Pro-apoptotic transcriptional targets of TP53 are TRAIL death receptors TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2), as well as the FASL/CD95L death receptor FAS (CD95). TRAIL receptors and FAS induce pro-apoptotic signaling in response to external stimuli via extrinsic apoptosis pathway (Wu et al. 1997, Takimoto et al. 2000, Guan et al. 2001, Liu et al. 2004, Ruiz de Almodovar et al. 2004, Liu et al. 2005, Schilling et al. 2009, Wilson et al. 2013). IGFBP3 is a transcriptional target of TP53 that may serve as a ligand for a novel death receptor TMEM219 (Buckbinder et al. 1995, Ingermann et al. 2010).
所含基因
12 个基因