高尔基体内交通
中文名称
通路描述
哺乳动物高尔基体至少由三个生物化学不同的囊泡组成：cis、medial 和 trans（reviewed in Szul and Sztul, 2011; Day et al, 2013）。高尔基体的结构和功能紧密相关，因此对于通过高尔基体进行蛋白质运输所需的蛋白质，通常也是高尔基体堆叠的组织所需，反之亦然（reviewed in Liu and Storrie, 2012; Liu and Storrie, 2015; Chia and Gleeson, 2014; Munro, 2011）。来自 ER 和 ERGIC 的新合成蛋白质在 cis 面接收，流向 trans 面，然后被释放到 trans 高尔基体网络（TGN），以便进一步分泌到溶酶体系统、质膜或细胞外区域。从高尔基体 trans 到 cis 囊泡的逆行流动将来自细胞外区域、质膜和溶酶体系统的内吞货物带回 ER。高尔基体内双向交通都由 COPI 载体介导，运输的特异性部分由参与 SNAREs、RABs 和 tethering 蛋白的互补性决定（reviewed in Szul and Sztul, 2011; Spang 2013; Willet et al, 2013; Chia and Gleeson, 2014）。
英文描述
Intra-Golgi traffic The mammalian Golgi consists of at least three biochemically distinct cisternae, cis-, medial- and trans (reviewed in Szul and Sztul, 2011; Day et al, 2013). The structure and function of the Golgi are tightly interconnected, such that proteins that are required for protein transport through the Golgi are often also required for the organization of the Golgi stacks, and vice versa (reviewed in Liu and Storrie, 2012; Liu and Storrie, 2015; Chia and Gleeson, 2014; Munro, 2011). Newly synthesized proteins from the ER and ERGIC are received at the cis face of the Golgi and flow through to the trans-Golgi before being released to the trans-Golgi network (TGN) for further secretion to the endolysosomal system, plasma membrane or extracellular region. Retrograde flow from the trans- to cis-cisternae moves endocytosed cargo from the extracellular region, the plasma membrane and the endolysosomal system back towards the ER. Intra-Golgi retrograde traffic also returns resident Golgi proteins to their appropriate cisternae, in this way facilitating cisternal remodeling or maturation (reviewed in Boncompain and Perez, 2013; Day et al, 2013). Intra-Golgi traffic in both directions is mediated by COPI carriers, with specificity of transport being determined at least in part by the complement of SNAREs, RABs and tethering proteins involved (reviewed in Szul and Sztul, 2011; Spang 2013; Willet et al, 2013; Chia and Gleeson, 2014).
所含基因
43 个基因