内质网中的前NOTCH加工
中文名称
通路描述
在内质网中，糖基转移酶通过糖基化NOTCH中EGF重复序列中保守的丝氨酸和苏氨酸残基来修饰NOTCH前体。O-半乳糖基转移酶POGLUT1（哺乳动物同源物Drosophila酶Rumi）在NOTCH的EGF重复序列中保守的丝氨酸残基上添加一个半乳糖基。O-半乳糖基转移酶POGLUT1、半乳糖基化和半乳糖基化对于NOTCH受体前体的功能都是必需的。
英文描述
Glycerophospholipid catabolism Reactions grouped in this pathway because of their shared chemistry - the hydrolysis of various phosphatidyl inositols and related phospholipids. They differ, however, in the tissues in which they occur and in their likely physiological roles. The activities of PNPLA6 and GDPD5 annotated here, for example, are especially prominent in kidney cells where the choline they generate plays a role in protecting cells from osmotic stress (Burg et al. 2007). Expression of others may be correlated with specific developmental events (Corda et al. 2013).
所含基因
7 个基因