flap 中间体的移除
中文名称
通路描述
两种核酸内切酶,Dna2 和 flap 内切酶 1(FEN-1),负责解决新生 flap 结构(Tsurimoto 和 Stillman, 1991)。酵母中的 Dna2 核酸内切酶/解旋酶是一个约 172 kDa 的单亚基。人类 FEN-1 是一个约 42 kDa 的单链多肽。复制蛋白 A 调节核酸内切酶在移除被置换 flap 时的转换(Tsurimoto 等人,1991)。
英文描述
Removal of the Flap Intermediate Two endonucleases, Dna2 and flap endonuclease 1 (FEN-1), are responsible for resolving the nascent flap structure (Tsurimoto and Stillman 1991). The Dna2 endonuclease/helicase in yeast is a monomer of approximately 172 kDa. Human FEN-1 is a single polypeptide of approximately 42 kDa. Replication Protein A regulates the switching of endonucleases during the removal of the displaced flap (Tsurimoto et al.1991).
所含基因
14 个基因