滞后链的连续合成
中文名称
通路描述
允许滞后链连续合成的关键事件是聚合酶从 Pol alpha 切换到 Pol delta，这与前导链类似。然而，滞后链的连续合成过程截然不同。DNA 合成是不连续的，涉及形成称为 Okazaki 片段的小片段。在 Okazaki 片段的合成过程中，RNA 引物折叠成单链凸起，并由内切酶切除。随后，相邻的 Okazaki 片段进行连接。
英文描述
Processive synthesis on the lagging strand The key event that allows the processive synthesis on the lagging strand, is polymerase switching from pol alpha to pol delta, as on the leading strand. However, the processive synthesis on the lagging strand proceeds very differently. DNA synthesis is discontinuous, and involves the formation of short fragments called the Okazaki fragments. During the synthesis of Okazaki fragments, the RNA primer is folded into a single-stranded flap, which is removed by endonucleases. This is followed by the ligation of adjacent Okazaki fragments.
所含基因
10 个基因