半乳糖分解代谢
中文名称
通路描述
人类饮食中半乳糖的主要来源是牛奶和乳制品。这些来源中的乳糖在肠道中被水解为葡萄糖和半乳糖。半乳糖主要在肝脏中代谢，通过三步反应生成每分子半乳糖产生一分子葡萄糖 1-磷酸。首先，半乳糖被磷酸化为半乳糖 1-磷酸。然后，半乳糖 1-磷酸和 UDP-葡萄糖反应生成 UDP-半乳糖和葡萄糖 1-磷酸，UDP-半乳糖发生异构化生成 UDP-葡萄糖。在与其他途径共享的反应中，葡萄糖 1-磷酸可转化为葡萄糖 6-磷酸（Holton 等，2001；Elsas 和 Lai，2001）。
英文描述
Galactose catabolism The main sources of galactose in the human diet are milk and milk products. The disaccharide lactose from these sources is hydrolyzed in the intestine to its constituent monosaccharides, glucose and galactose. Galactose is metabolized primarily in the liver in a sequence of three reactions that yield one molecule of glucose 1-phosphate per molecule of galactose. First, it is phosphorylated to yield galactose 1-phosphate. Then, galactose 1-phosphate and UDP-glucose react to form UDP-galactose and glucose 1-phosphate, and UDP-galactose undergoes epimerization to form UDP-glucose. In a reaction shared with other pathways, glucose 1-phosphate can be converted into glucose 6-phosphate (Holton et al. 2001; Elsas and Lai 2001).
所含基因
6 个基因