结合帽结合复合物和eIFs后mRNA的激活及随后与43S的结合
中文名称
通路描述
结合帽结合复合物和eIFs后mRNA的激活及随后与43S的结合。帽结合复合物由起始因子eIF4A、eIF4G和eIF4E组成。首先，eIF4E必须从无活性的eIF4E:4E-BP复合物中释放。然后eIF4A与eIF4G相互作用，eIF4E结合到eIF4G的N端结构域，形成帽结合复合物eIF4F。eIF4A与eIF4B或eIF4H一起被认为解开mRNA 5'端附近的RNA二级结构。当43S复合物结合到帽结合mRNA时，形成翻译起始复合物。
英文描述
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S The cap-binding complex is constituted by the initiation factors eIF4A, eIF4G and eIF4E. First, eIF4E must be released from the inactive eIF4E:4E-BP complex. Then eIF4A interacts with eIF4G, and eIF4E binds to the amino-terminal domain of eIF4G, resulting in the formation of the cap-binding complex eIF4F. eIF4A together with eIF4B or eIF4H is thought to unwind RNA secondary structures near the 5'-end of the mRNA. The translation initiation complex is formed when the 43S complex binds the cap-bound mRNA.
所含基因
7 个基因