核苷酸糖的转运
中文名称
通路描述
核苷酸糖用作糖供体，由糖基转移酶用于创建糖链，形成糖蛋白、多糖和糖脂等糖共轭物的糖链。糖基转移酶主要位于高尔基体腔和内质网（ER）中，而核苷酸糖则在细胞质中合成。人类溶质载体家族 SLC35 编码核苷酸糖转运体（NSTs），这些转运体可以介导核苷酸糖的反转运，以相应的核苷酸单磷酸（例如 UMP 用于 UDP 糖）为交换物。由于其功能，NSTs 主要位于高尔基体和 ER 膜上（He L 等人，2009；Handford M 等人，2006；Ishida N 和 Kawakita M，2004）。
英文描述
Transport of nucleotide sugars Nucleotide sugars are used as sugar donors by glycosyltransferases to create the sugar chains for glycoconjugates such as glycoproteins, polysaccharides and glycolipids. Glycosyltransferases reside mainly in the lumen of the Golgi apparatus and endoplasmic reticulum (ER) whereas nucleotide sugars are synthesized in the cytosol. The human solute carrier family SLC35 encode nucleotide sugar transporters (NSTs) which can mediate the antiport of nucleotide sugars in exchange for the corresponding nucleoside monophosphates (eg. UMP for UDP-sugars). Owing to their function, NSTs are primarily located on Golgi and ER membranes (He L et al, 2009; Handford M et al, 2006; Ishida N and Kawakita M, 2004).
所含基因
9 个基因