嘧啶分解代谢
中文名称
通路描述
嘧啶分解代谢包括一系列反应，胸腺嘧啶被转化为β-氨基异丁酸，尿嘧啶被转化为β-丙氨酸。这两种分子均出现在人体尿液中，似乎是嘧啶分解代谢的正常终产物（Griffith 1986; Webster et al. 2001）。然而，线粒体 AGXT2 也能催化这两种分子的转氨基作用，与丙酮酸结合，生成 2-酮酸，后者可进一步通过支链氨基酸和短链脂肪酸分解代谢的反应进行代谢。这些反应在正常人体嘧啶分解代谢中的重要性尚未得到充分研究。
英文描述
Pyrimidine catabolism In parallel sequences of three reactions each, thymine is converted to beta-aminoisobutyrate and uracil is converted to beta-alanine. Both of these molecules are excreted in human urine and appear to be normal end products of pyrimidine catabolism (Griffith 1986; Webster et al. 2001). Mitochondrial AGXT2, however, can also catalyze the transamination of both molecules with pyruvate, yielding 2-oxoacids that can be metabolized further by reactions of branched-chain amino acid and short-chain fatty acid catabolism (Tamaki et al. 2000). The importance of these reactions in normal human pyrimidine catabolism has not been well worked out.
所含基因
11 个基因