嘌呤核糖核苷一磷酸生物合成
中文名称
通路描述
嘌呤核糖核苷一磷酸（IMP）在 5'-磷酸-alpha-D-核糖 1,5-二磷酸（PRPP）上组装，原子来自天冬氨酸、谷氨酰胺、甘氨酸、N10-甲酰四氢叶酸和二氧化碳。虽然该序列中的个别反应是可逆的，如图中所示的双向箭头所示，但其他不可逆步骤驱动该途径在正常细胞中向 IMP 合成的方向进行。所有这些反应因此仅在此标注为 IMP 合成的方向。鸟苷酸 5'-磷酸一磷酸（GMP）和腺苷酸 5'-磷酸（AMP）从 IMP 合成。
英文描述
Purine ribonucleoside monophosphate biosynthesis The purine ribonucleotide inosine 5'-monophosphate (IMP) is assembled on 5-phospho-alpha-D-ribose 1-diphosphate (PRPP), with atoms derived from aspartate, glutamine, glycine, N10-formyl-tetrahydrofolate, and carbon dioxide. Although several of the individual reactions in this sequence are reversible, as indicated by the double-headed arrows in the diagram, other irreversible steps drive the pathway in the direction of IMP synthesis in the normal cell. All of these reactions are thus annotated here only in the direction of IMP synthesis. Guanosine 5'-monophosphate (GMP) and adenosine 5'-monophosphate (AMP) are synthesized from IMP.
所含基因
11 个基因