RNA Polymerase III Transcription Termination

RNA Polymerase III Transcription Termination At the end of the cycle, the elongation complex (EC) must be destabilized to release its transcript and DNA. Analogous to initiation, cis-signals and protein factors are required to mediate EC destabilization and release of the transcript from the grip of the RNA polymerase (RNAP). RNAP III achieves efficient termination despite the apparent simplicity of its cis-acting DNA terminator element, a stretch of five or more T residues on the non-template (NT) strand, which directs termination within this site without need for additional cis-elements or trans-acting factors.