IRS 激活
中文名称
通路描述
IRS 是胰岛素信号事件的一个介质。它通过磷酸化而被激活，触发涉及 PI3K、SOS、RAF 和 MAP 激酶的级联反应。IRS 下方提到的蛋白质是 IRS 家族成员的例子，如所指示的。未来将确认并添加更多家族成员。通过受体突变研究已知，IRS1 通过其 PTB 域在酪氨酸 972 处的 juxtamembrane 区域与胰岛素受体结合。IRS1 的 PH 域通过与细胞膜磷脂相互作用进一步稳定这种相互作用。这允许受体将 IRS1 磷酸化多达 13 个酪氨酸残基。一旦磷酸化，IRS1 就从受体上脱落。现在在酪氨酸磷酸化且因此处于激活状态的蛋白质，其他蛋白质可以与 IRS 蛋白相互作用。
英文描述
IRS activation IRS is one of the mediators of insulin signalling events. It is activated by phosphorylation and triggers a cascade of events involving PI3K, SOS, RAF and the MAP kinases. The proteins mentioned under IRS are examples of IRS family members acting as indicated. More family members are to be confirmed and added in the future. Using receptor mutagenesis studies it is known that IRS1 via its PTB domain binds to the insulin receptor at the juxtamembrane region at tyrosine 972. The interaction is further stabilized by the PH domain of IRS1 which interacts with the phospholipids of the plasma membrane. This allows the receptor to phosphorylate IRS1 on up to 13 of its tyrosine residues. Once phosphorylated the IRS1 falls away from the receptor. Now in a tyrosine phosphorylated and hence activated state other proteins can interact with the IRS proteins.
所含基因
5 个基因