Chk1/Chk2(Cds1)介导的Cyclin B:Cdk1复合物失活
中文名称
通路描述
DNA损伤诱导的检查点激酶Chk1/Chk2(Cds1)的激活导致CyclinB:Cdc2复合物处于酪氨酸15磷酸化（无活性）状态。Cdc2活性受Wee1/Myt1激酶和Cdc25磷酸酶之间磷酸化和去磷酸化平衡的调节。Cyclin B:Cdc2复合物的失活可能涉及Cdc25的失活和/或Wee1/Myt1激酶活性的增强。
英文描述
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex DNA damage induced activation of the checkpoint kinases Chk1/Chk2(Cds1) results in the conversion and/or maintenance of CyclinB:Cdc2 complex in its Tyrosine 15 phosphorylated (inactive) state. Cdc2 activity is regulated by a balance between the phosphorylation and dephosphorylation by the Wee1/Myt1 kinase and Cdc25 phosphatase. Inactivation of the Cyclin B:Cdc2 complex likely involves both inactivation of Cdc25 and/or stimulation of Wee1/Myt1 kinase activity.
所含基因
15 个基因