SARS-CoV-2 靶向细胞 - 细胞连接中的 PDZ 蛋白
中文名称
通路描述
PDZ 结构域是蛋白质 - 蛋白质识别序列，由 80-90 个氨基酸组成，结合到靶蛋白的羧基末端 PBM 上。含有 PDZ 结构域的蛋白质通常位于细胞质或与细胞膜结合，参与细胞 - 细胞连接、细胞极性及信号转导等多种细胞过程。PDZ 结构域的多结构域特性使其能够同时与多个结合伙伴相互作用，从而组装更大的蛋白质复合物。病毒还编码含有 PBM 的蛋白质，这些病毒 PBM 靶向参与紧密连接形成、细胞极性建立和凋亡的细胞 PDZ 蛋白。
英文描述
RNA Polymerase II Transcription Initiation Formation of the open complex exposes the template strand to the catalytic center of the RNA polymerase II enzyme. This facilitates formation of the first phosphodiester bond, which marks transcription initiation. As a result of this, the TFIIB basal transcription factor dissociates from the initiation complex.The open transcription initiation complex is unstable and can revert to the closed state. Initiation at this stage requires continued (d)ATP-hydrolysis by TFIIH. Dinucleotide transcripts are not stably associated with the transcription complex. Upon dissociation they form abortive products. The transcription complex is also sensitive to inhibition by small oligo-nucleotides. Dinucleotides complementary to position -1 and +1 in the template can also direct first phosphodiester bond formation. This reaction is independent on the basal transcription factors TFIIE and TFIIH and does not involve open complex formation. This reaction is sensitive to inhibition by single-stranded oligonucleotides.
所含基因
48 个基因