RNA 聚合酶 II 转录起始和启动子清除
中文名称
通路描述
转录循环分为三个主要阶段：起始、延伸和终止。转录起始包括启动子 DNA 结合、DNA 解链和短 RNA 转录本的首次合成。为了从起始阶段过渡到转录本延伸，RNA 聚合酶 II（pol II）转录复合物必须发生许多变化。在转录的中间阶段，与起始因子的接触丧失，新生转录本的稳定结合得以建立。这些变化共同构成了启动子清除。
英文描述
RNA Polymerase II Transcription Initiation And Promoter Clearance The transcription cycle is divided in three major phases: initiation, elongation, and termination. Transcription initiation include promoter DNA binding, DNA melting, and initial synthesis of short RNA transcripts. Many changes must occur to the RNA polymerase II (pol II) transcription complex as it makes the transition from initiation into transcript elongation. During this intermediate phase of transcription, contact with initiation factors is lost and stable association with the nascent transcript is established. These changes collectively comprise promoter clearance.
所含基因
48 个基因