RNA 聚合酶 III 从类型 1 启动子转录起始
中文名称
通路描述
类型 1 启动子招募 TFIIIA，它是 C2H2 锌指家族 DNA 结合蛋白（Engelke et al., 1980; Sakonju et al., 1981）的奠基成员。TFIIIA 的结合随后允许 TFIIC（Lassar et al., 1983）的结合，这是一个由五个亚基组成的复合物（与酿酒酵母中的六个亚基不同），在人类细胞和酿酒酵母中。一旦形成 DNA/TFIIIA/TFIIIC 复合物，Brf1-TFIIIB 就加入复合物，这进而允许招募 RNA 聚合酶 III（Bieker et al., 1985; Setzer and Brown, 1985）。
英文描述
RNA Polymerase III Transcription Initiation From Type 1 Promoter The type 1 promoters recruit TFIIIA, the founding member of the C2H2 zinc finger family of DNA-binding proteins (Engelke et al., 1980; Sakonju et al., 1981). The binding of TFIIIA then allows the binding of TFIIC (Lassar et al., 1983), a complex consisting of five subunits (which differs from the six subunits in S. cerevisiae) in human cells and S. pombe. Once the DNA/TFIIIA/TFIIIC complex is formed, Brf1-TFIIIB joins the complex and this in turn allows the recruitment of RNA polymerase III (Bieker et al., 1985; Setzer and Brown, 1985).
所含基因
28 个基因