棕榈酰-CoA到肉豆蔻酰-CoA的β-氧化
中文名称
通路描述
β-氧化螺旋的第三次通过始于饱和脂肪酸棕榈酰-CoA，产生肉豆蔻酰-CoA。需要四个酶促步骤，起始于长链酰-CoA脱氢酶（LCAD）活性，随后是顺式-2-烯酰-CoA水合酶（crotonase）的烯酰-CoA水合酶活性，由短链3-羟基酰-CoA脱氢酶（SCHAD）的3-羟基酰-CoA脱氢酶活性完成，最后由酮酰-CoA硫解酶活性完成，该活性存在于与线粒体膜相关的三功能蛋白中。请注意，SCHAD的3-羟基酰-CoA脱氢酶活性实际上并不局限于短链脂肪酸，事实上SCHAD具有广泛的底物特异性。
英文描述
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA The third pass through the beta-oxidation spiral picks up where the last left off with the saturated fatty acid lauroyl-CoA and produces decanoyl-CoA. Four enzymatic steps are required starting with LCAD CoA dehydrogenase (Long Chain) activity, followed by the enoyl-CoA hydratase activity of crotonase, the 3-hydroxyacyl-CoA dehydrogenase activity of the short chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), and completed by the ketoacyl-CoA thiolase activity, present in the mitochondrial membrane associated trifunctional protein. Note that the 3-hydroxyacyl-CoA dehydrogenase activity of SCHAD is not actually limited to short chain fatty acids, in fact SCHAD has a broad substrate specificity.
所含基因
5 个基因